MTF2 antibody
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- Target See all MTF2 Antibodies
- MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MTF2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- metal response element binding transcription factor 2
- Isotype
- IgG
- Top Product
- Discover our top product MTF2 Primary Antibody
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- Application Notes
- WB: 1:500-1:1000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
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- Target
- MTF2 (Metal Response Element Binding Transcription Factor 2 (MTF2))
- Alternative Name
- MTF2 (MTF2 Products)
- Synonyms
- mtf2a antibody, xpcl2 antibody, MGC132044 antibody, m96 antibody, pcl2 antibody, Xpcl2 antibody, wu:cegs2813 antibody, zgc:136399 antibody, M96 antibody, PCL2 antibody, RP5-976O13.1 antibody, TDRD19A antibody, dJ976O13.2 antibody, 9230112N11Rik antibody, AA537621 antibody, C76717 antibody, Pcl2 antibody, RGD1304727 antibody, metal response element binding transcription factor 2 antibody, metal response element binding transcription factor 2 S homeolog antibody, MTF2 antibody, mtf2.S antibody, mtf2 antibody, Mtf2 antibody
- Background
- Synonyms:hPCl2, M96, MTF2, PCL2, Polycomb like protein 2, RP5 976O13.1 Background:Polycomb group(PcG) that specifically binds histone H3 trimethylated at 'Lys-36'(H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element(MRE) of MT1A gene promoter(By similarity).
- Molecular Weight
- 60-61 kDa
- Gene ID
- 22823
- UniProt
- Q9Y483
- Pathways
- Stem Cell Maintenance
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