MAML1 antibody
-
- Target See all MAML1 Antibodies
- MAML1 (Mastermind-Like 1 (MAML1))
-
Reactivity
- Human, Mouse, Rat
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This MAML1 antibody is un-conjugated
-
Application
- ELISA, Western Blotting (WB)
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- mastermind-like 1(Drosophila)
- Isotype
- IgG
- Top Product
- Discover our top product MAML1 Primary Antibody
-
-
- Application Notes
- WB: 1:500-1:2000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
-
- Target
- MAML1 (Mastermind-Like 1 (MAML1))
- Alternative Name
- MAML1 (MAML1 Products)
- Synonyms
- mam1 antibody, mam-1 antibody, xmam1 antibody, MAML1 antibody, AI644666 antibody, AW743257 antibody, D930008C07Rik antibody, Mam-1 antibody, Mam1 antibody, mKIAA0200 antibody, mastermind like transcriptional coactivator 1 L homeolog antibody, mastermind like transcriptional coactivator 1 antibody, mastermind like 1 (Drosophila) antibody, mastermind-like transcriptional coactivator 1 antibody, maml1.L antibody, MAML1 antibody, Maml1 antibody
- Background
- Synonyms:KIAA0200 Background:Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
- Molecular Weight
- 108-120kd
- Gene ID
- 9794
- UniProt
- Q92585
- Pathways
- Notch Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
-