KLHL22 antibody
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- Target See all KLHL22 Antibodies
- KLHL22 (Kelch-Like 22 (KLHL22))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KLHL22 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- kelch-like 22(Drosophila)
- Isotype
- IgG
- Top Product
- Discover our top product KLHL22 Primary Antibody
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- Application Notes
- WB: 1:500-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
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- Target
- KLHL22 (Kelch-Like 22 (KLHL22))
- Alternative Name
- KLHL22 (KLHL22 Products)
- Synonyms
- 2610318I18Rik antibody, Kelchl antibody, KELCHL antibody, RGD1306288 antibody, kelch-like 22 antibody, kelch like family member 22 antibody, kelch-like family member 22 antibody, Klhl22 antibody, KLHL22 antibody
- Background
- Synonyms: Background:Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint(SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
- Molecular Weight
- 72 kDa
- Gene ID
- 84861
- UniProt
- Q53GT1
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