IFIT2 antibody

Catalog No. ABIN7115383

Product Details anti-IFIT2 Antibody

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: interferon-induced protein with tetratricopeptide repeats 2

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IHC: 1:50-1:500, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for IFIT2

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Alternative Name: IFIT2 (IFIT2 Products)

Synonyms: G10P2 antibody, GARG-39 antibody, IFI-54 antibody, IFI-54K antibody, IFI54 antibody, IFIT-2 antibody, ISG-54 K antibody, ISG-54K antibody, ISG54 antibody, P54 antibody, cig42 antibody, wu:fb58d07 antibody, DKFZp468G198 antibody, AV302338 antibody, Ifi54 antibody, interferon induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 15 antibody, IFIT2 antibody, Ifit2 antibody, ifit15 antibody

Background: Synonyms:cig42, G10P2, GARG 39, IFI 54, IFI 54K, IFI54, IFIT 2, IFIT2, ISG 54 K, ISG 54K, ISG54 Background:IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Molecular Weight: 50-55 kDa

Gene ID: 3433

UniProt: P09913