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IGKV1-5 antibody

IGKV1-5 Reactivity: Human, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7115198
  • Target See all IGKV1-5 products
    IGKV1-5 (Immunoglobulin kappa Variable 1-5 (IGKV1-5))
    Reactivity
    Human, Mouse
    Host
    • 1
    • 1
    Rabbit
    Clonality
    • 2
    Polyclonal
    Conjugate
    • 2
    This IGKV1-5 antibody is un-conjugated
    Application
    Western Blotting (WB), ELISA
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    immunoglobulin kappa variable 1-5
    Isotype
    IgG
  • Application Notes
    WB: 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    IGKV1-5 (Immunoglobulin kappa Variable 1-5 (IGKV1-5))
    Alternative Name
    IGKV1-5 (IGKV1-5 Products)
    Synonyms
    IGKV antibody, IGKV15 antibody, L12 antibody, L12a antibody, V1 antibody, immunoglobulin kappa variable 1-5 antibody, IGKV1-5 antibody
    Background
    Synonyms: Background:V segment of the variable domain of immunoglobulins light chain that participates to the antigen recognition. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens(PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen(PubMed:20176268, PubMed:17576170).
    UniProt
    P01602
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