FBXO2 antibody

Catalog No. ABIN7114045

Product Details anti-FBXO2 Antibody

Target: FBXO2 (F-Box Protein 2 (FBXO2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: F-box protein 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for FBXO2

Target: FBXO2 (F-Box Protein 2 (FBXO2))

Alternative Name: FBXO2 (FBXO2 Products)

Synonyms: FBG1 antibody, FBX2 antibody, Fbs1 antibody, NFB42 antibody, OCP1 antibody, Fbs2 antibody, Prpl4 antibody, F-box protein 2 antibody, FBXO2 antibody, Fbxo2 antibody

Background: Synonyms:FBX2 Background:Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type(By similarity).

Molecular Weight: 33-40 kDa

Gene ID: 26232

UniProt: Q9UK22