Exportin 7 antibody

Catalog No. ABIN7114023

Product Details anti-Exportin 7 Antibody

Target: Exportin 7 (XPO7)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: exportin 7

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Exportin 7

Target: Exportin 7 (XPO7)

Alternative Name: XPO7 (XPO7 Products)

Background: Synonyms:Exp7, exportin 7, KIAA0745, Ran binding protein 16, RANBP16, XPO7 Background:Mediates the nuclear export of proteins(cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP(induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus.

Molecular Weight: 100 kDa

Gene ID: 23039

UniProt: Q9UIA9