ERLIN2 antibody

Catalog No. ABIN7113871

This Rabbit Polyclonal antibody specifically detects ERLIN2 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ERLIN2 antibody (ABIN7113871)

Target: ERLIN2 (ER Lipid Raft Associated 2 (ERLIN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERLIN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ERLIN2 Antibody

Purpose: ERLIN2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ER lipid raft associated 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ERLIN2

Target: ERLIN2 (ER Lipid Raft Associated 2 (ERLIN2))

Alternative Name: ERLIN2

Background:

Synonyms: Erlin-2|Endoplasmic reticulum lipid raft-associated protein 2|Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 (SPFH domain-containing protein 2)|ERLIN2|C8orf2|SPFH2

Background: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation(ERAD) of inositol 1,4,5-trisphosphate receptors(IP3Rs) such as ITPR1(PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex(PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex(PubMed:24217618).

Molecular Weight: 38 kDa

Gene ID: 11160

UniProt: O94905