ERLIN2 antibody

Catalog No. ABIN7113871

Product Details anti-ERLIN2 Antibody

Target: ERLIN2 (ER Lipid Raft Associated 2 (ERLIN2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERLIN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ER lipid raft associated 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for ERLIN2

Target: ERLIN2 (ER Lipid Raft Associated 2 (ERLIN2))

Alternative Name: ERLIN2 (ERLIN2 Products)

Synonyms: C8orf2 antibody, Erlin-2 antibody, NET32 antibody, SPFH2 antibody, SPG18 antibody, BC036333 antibody, C87251 antibody, Spfh2 antibody, Erlin-2-B antibody, erlin1 antibody, spfh1 antibody, spfh2 antibody, spfh2-B antibody, RGD1309010 antibody, SPFH domain-containing protein 2-A antibody, erlin2 antibody, erlin2-a antibody, erlin2-b antibody, spfh2-A antibody, ER lipid raft associated 2 antibody, erlin-2 antibody, Erlin-2 antibody, ER lipid raft associated 2 S homeolog antibody, ER lipid raft associated 2 L homeolog antibody, ERLIN2 antibody, erlin2 antibody, Tsp_03442 antibody, erln2 antibody, Erlin2 antibody, erlin2.S antibody, erlin2.L antibody

Background: Synonyms:C8orf2, SPFH2 Background:Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation(ERAD) of inositol 1,4,5-trisphosphate receptors(IP3Rs) such as ITPR1(PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex(PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex(PubMed:24217618).

Molecular Weight: 38 kDa

Gene ID: 11160

UniProt: O94905