DNAJA1 antibody

Catalog No. ABIN7113564

Product Details anti-DNAJA1 Antibody

Target: DNAJA1 (DnaJ (Hsp40) Homolog, Subfamily A, Member 1 (DNAJA1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: DnaJ(Hsp40) homolog, subfamily A, member 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for DNAJA1

Target: DNAJA1 (DnaJ (Hsp40) Homolog, Subfamily A, Member 1 (DNAJA1))

Alternative Name: DNAJA1 (DNAJA1 Products)

Background: Synonyms:DJ 2, DjA1, DnaJ protein homolog 2, DNAJ2, DNAJA1, hDJ 2, HDJ2, Heat shock 40 kDa protein 4, Heat shock protein J2, HSDJ, HSJ 2, HSJ2, HSPF4, Human DnaJ protein 2 Background:Co-chaperone for HSPA8/Hsc70(PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A(in vitro)(PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis(PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV(PubMed:24512202).

Molecular Weight: 45 kDa

Gene ID: 3301

UniProt: P31689

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway