RGD1307927 antibody, FAM31A antibody, KIAA1608 antibody, RP11-230L22.3 antibody, 6030446I19Rik antibody, connecdenn antibody, fam31a antibody, DENN domain containing 1A antibody, DENN/MADD domain containing 1A antibody, DENN domain-containing protein 1A antibody, DENN domain containing 1A S homeolog antibody, Dennd1a antibody, DENND1A antibody, dennd1a antibody, LOC100512328 antibody, dennd1a.S antibody
Background
Synonyms:FAM31A, KIAA1608 Background:Guanine nucleotide exchange factor(GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes(PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates(PtdInsPs), with some preference for PtdIns(3)P(By similarity).