DOCK7 antibody

Catalog No. ABIN7113381

Product Details anti-DOCK7 Antibody

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: dedicator of cytokinesis 7

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IP: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for DOCK7

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Alternative Name: DOCK7 (DOCK7 Products)

Synonyms: im:7145816 antibody, im:7157388 antibody, wu:fb93h07 antibody, ZIR2 antibody, 3110056M06Rik antibody, Gm430 antibody, m antibody, mKIAA1771 antibody, dedicator of cytokinesis 7 antibody, dedicator of cytokinesis protein 7 antibody, dedicator of cytokinesis 6 antibody, DOCK7 antibody, dock7 antibody, NAEGRDRAFT_56982 antibody, LOC100185115 antibody, dock6 antibody, Dock7 antibody

Background: Synonyms:dedicator of cytokinesis 7, DOCK7, KIAA1771, ZIR2 Background:Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation, negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.

Molecular Weight: 240 kDa

Gene ID: 85440

UniProt: Q96N67