CHMP2A antibody
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- Target See all CHMP2A Antibodies
- CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CHMP2A antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Immunogen affinity purified
- Purity
- ≥95 % as determined by SDS-PAGE
- Immunogen
- chromatin modifying protein 2A
- Isotype
- IgG
- Top Product
- Discover our top product CHMP2A Primary Antibody
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- Application Notes
- WB: 1:500-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- Expiry Date
- 12 months
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- Target
- CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))
- Alternative Name
- CHMP2A (CHMP2A Products)
- Synonyms
- BC-2 antibody, BC2 antibody, CHMP2 antibody, VPS2 antibody, VPS2A antibody, 1500016L11Rik antibody, RGD1305050 antibody, bc-2 antibody, bc2 antibody, chmp2 antibody, vps2 antibody, vps2a antibody, fj10d05 antibody, wu:fi18h03 antibody, wu:fj10d05 antibody, zgc:55361 antibody, charged multivesicular body protein 2a antibody, charged multivesicular body protein 2A antibody, Charged multivesicular body protein 2a antibody, charged multivesicular body protein 2A L homeolog antibody, ATEG_06167 antibody, LOC5570080 antibody, EDI_289610 antibody, PTRG_09933 antibody, NAEGRDRAFT_39042 antibody, PITG_17335 antibody, Tsp_00033 antibody, LOC100284170 antibody, LOC100284688 antibody, chm2a antibody, chmp2a antibody, CHMP2A antibody, Chmp2a antibody, chmp2a.L antibody
- Background
- Synonyms:BC2, CHMP2 Background:Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis(PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase(PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses(HIV-1 and other lentiviruses). Involved in HIV-1 p6-and p9-dependent virus release.
- Molecular Weight
- 32 kDa
- Gene ID
- 27243
- UniProt
- O43633
- Pathways
- SARS-CoV-2 Protein Interactome
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