CEP63 antibody

Catalog No. ABIN7112613

Product Details anti-CEP63 Antibody

Target: CEP63 (Centrosomal Protein 63kDa (CEP63))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP63 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: centrosomal protein 63kDa

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for CEP63

Target: CEP63 (Centrosomal Protein 63kDa (CEP63))

Alternative Name: CEP63 (CEP63 Products)

Synonyms: 4921501M07 antibody, AL450317.13gm1 antibody, AW107703 antibody, CD20R antibody, D9Mgc41 antibody, D9Mgc48e antibody, ET2 antibody, zgc:63548 antibody, Cep63-A antibody, Cep63-B antibody, Xcep63 antibody, centrosomal protein 63 antibody, centrosomal protein 63kDa antibody, centrosomal protein 63kDa L homeolog antibody, CEP63 antibody, SYO3AOP1_1060 antibody, Cep63 antibody, cep63 antibody, cep63.L antibody

Background: Synonyms: Background:Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152, however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes, this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).

Molecular Weight: 57-75kd

Gene ID: 80254

UniProt: Q96MT8

Pathways: M Phase