CEP290 antibody

Catalog No. ABIN7112607

Product Details anti-CEP290 Antibody

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: centrosomal protein 290kDa

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IP: 1:500-1:5000, IHC: 1:20-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290 (CEP290 Products)

Background: Synonyms:BBS14, KIAA0373, NPHP6,LCA10, MKS4, Nephrocystin 6, rd16, SLSN6, Tumor antigen se2 2 Background:Studies in the Chlamydomonas model system has shown that the ciliary protein CEP290 is a critical component of these Y-link junctions. Additionally, numerous studies have demonstrated that CEP290's function is critical for IFT-in CEP290 knockdown experiments, many proteins that would normally localize to the cilium fail to do so, and cilium formation is disrupted or absent. Mutations in CEP290 are accountable for cases of nephronophthisis, Leber congenital amaurosis and Joubert syndrome. In IF analtsis of HeLa cells, the white arrows show centrosome and cilium staining.

Molecular Weight: 290 kDa, 150-180 kDa, 80 kDa, 60 kDa

Gene ID: 80184

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase