unm antibody, hi3634 antibody, un-named antibody, zgc:92188 antibody, id:ibd2033 antibody, si:dz241h12.3 antibody, si:busm1-241h12.3 antibody, cenpn-a antibody, cenpn-B antibody, cenp-n antibody, BM039 antibody, C16orf60 antibody, CENP-N antibody, ICEN32 antibody, 2610510J17Rik antibody, AI426416 antibody, AW545024 antibody, Da2-27 antibody, Da2-4 antibody, RGD1310953 antibody, centromere protein N antibody, centromere protein N S homeolog antibody, centromere protein N L homeolog antibody, cenpn antibody, CENPN antibody, cenpn.S antibody, cenpn.L antibody, Cenpn antibody
Background
Synonyms:C16orf60, ICEN32 Background:Component of the CENPA-NAC(nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD(nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.