BCCIP antibody

Catalog No. ABIN7112053

Product Details anti-BCCIP Antibody

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCCIP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: BRCA2 and CDKN1A interacting protein

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:100 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3 ,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for BCCIP

Target: BCCIP (BRCA2 and CDKN1A Interacting Protein (BCCIP))

Alternative Name: BCCIP (BCCIP Products)

Synonyms: zgc:110272 antibody, mp:zf637-1-000774 antibody, BCCIP antibody, DKFZp459K2416 antibody, MGC82792 antibody, tok-1 antibody, MGC89311 antibody, TOK-1 antibody, TOK1 antibody, 1110013J05Rik antibody, BRCA2 and CDKN1A interacting protein antibody, BRCA2 and CDKN1A interacting protein L homeolog antibody, BCCIP antibody, bccip antibody, bccip.L antibody, Bccip antibody

Background: Synonyms:TOK1 Background:This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 50 kDa

Gene ID: 56647

UniProt: Q9P287