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BHLHE22 antibody

BHLHE22 Reactivity: Human, Mouse WB, ELISA, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7111942
  • Target See all BHLHE22 Antibodies
    BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))
    Reactivity
    • 21
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 18
    • 2
    • 1
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    This BHLHE22 antibody is un-conjugated
    Application
    • 21
    • 15
    • 12
    • 12
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Purification
    Immunogen affinity purified
    Purity
    ≥95 % as determined by SDS-PAGE
    Immunogen
    basic helix-loop-helix family, member e22
    Isotype
    IgG
    Top Product
    Discover our top product BHLHE22 Primary Antibody
  • Application Notes
    WB: 1:200-1:1000, IF: 1:10-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Expiry Date
    12 months
  • Target
    BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))
    Alternative Name
    BHLHE22 (BHLHE22 Products)
    Synonyms
    bhlhb5 antibody, MGC145865 antibody, BHLHE22 antibody, Beta3.1 antibody, wu:fq25e11 antibody, zgc:64225 antibody, BHLHB5 antibody, Beta3 antibody, CAGL85 antibody, TNRC20 antibody, Bhlhb5 antibody, basic helix-loop-helix family member e22 antibody, basic helix-loop-helix family, member e22 antibody, bhlhe22 antibody, BHLHE22 antibody, Bhlhe22 antibody
    Background
    Synonyms:BHLHB5, TNRC20 Background:Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.
    Molecular Weight
    37 kDa
    Gene ID
    27319
    UniProt
    Q8NFJ8
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