BBS2 antibody

Catalog No. ABIN7111932

Product Details anti-BBS2 Antibody

Target: BBS2 (Bardet-Biedl Syndrome 2 (BBS2))

Reactivity: Human, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This BBS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Bardet-Biedl syndrome 2

Clone: 9F10

Isotype: IgG2a

Application Details

Application Notes: WB: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for BBS2

Target: BBS2 (Bardet-Biedl Syndrome 2 (BBS2))

Alternative Name: BBS2 (BBS2 Products)

Synonyms: fb80a05 antibody, wu:fb80a05 antibody, DKFZp468B105 antibody, DKFZp469L0919 antibody, BBS antibody, 2410125H22Rik antibody, AI447581 antibody, Bardet-Biedl syndrome 2 antibody, bardet-biedl syndrome 2 antibody, Bardet-Biedl syndrome 2 (human) antibody, bbs2 antibody, BBS2 antibody, Bbs2 antibody

Background: Synonyms: Background:The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor(GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog(SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Molecular Weight: 80 kDa

Gene ID: 583

UniProt: Q9BXC9

Pathways: Hedgehog Signaling