adh-8 antibody, adh8 antibody, zgc:77479 antibody, ADHFE1 antibody, ADH8 antibody, HOT antibody, 6330565B14Rik antibody, AI043035 antibody, Adh8 antibody, alcohol dehydrogenase, iron containing 1 antibody, alcohol dehydrogenase, iron containing, 1 antibody, alcohol dehydrogenase, iron containing 1 S homeolog antibody, adhfe1 antibody, ADHFE1 antibody, adhfe1.S antibody, Adhfe1 antibody
Background
Synonyms:ADH8, ADHFE1, FLJ32430, HMFT2263, HOT Background:Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate(GHB) to succinic semialdehyde(SSA) coupled to reduction of 2-ketoglutarate(2-KG) to D-2-hydroxyglutarate(D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate(L-3-OHB) are also substrates for HOT with 10-fold lower activities.