JAML antibody

Catalog No. ABIN7111354

Product Details anti-JAML Antibody

Target: JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JAML antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: adhesion molecule, interacts with CXADR antigen 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for JAML

Target: JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))

Alternative Name: JAML (AMICA1 Products)

Synonyms: RGD1562572 antibody, AMICA antibody, CREA7-1 antibody, CREA7-4 antibody, Gm638 antibody, JAML antibody, Crea7 antibody, junction adhesion molecule like antibody, Jaml antibody, JAML antibody

Background: Synonyms:AMICA1 Background:Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Molecular Weight: 30kd,44kd,50-60kd

Gene ID: 120425

UniProt: Q86YT9