ABHD2 antibody

Catalog No. ABIN7111166

Product Details anti-ABHD2 Antibody

Target: ABHD2 (Abhydrolase Domain Containing 2 (ABHD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABHD2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: abhydrolase domain containing 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for ABHD2

Target: ABHD2 (Abhydrolase Domain Containing 2 (ABHD2))

Alternative Name: ABHD2 (ABHD2 Products)

Background: Synonyms:ABHD2, Protein PHPS1 2, HS1 2, Lung alpha/beta hydrolase 2, LABH2 Background:Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol(AG) from cell membrane(PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol(1AG) and 2-arachidonoylglycerol(2AG) to glycerol and arachidonic acid(AA)(PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation(PubMed:26989199). May also play a role in smooth muscle cells migration(By similarity).

Molecular Weight: 48 kDa

Gene ID: 11057

UniProt: P08910