SREBF chaperone antibody (AA 41-140)

Catalog No. ABIN7091694

Product Details anti-SREBF chaperone Antibody

Target: SREBF chaperone (SCAP)

Binding Specificity: AA 41-140

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SREBF chaperone antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Human

Immunogen: KLH conjugated synthetic peptide derived from human SCAP

Clone: B7T5

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SREBF chaperone

Target: SREBF chaperone (SCAP)

Alternative Name: SCAP (SCAP Products)

Synonyms: 9530044G19 antibody, mKIAA0199 antibody, SREBF chaperone antibody, SREBF chaperone S homeolog antibody, SCAP antibody, Scap antibody, scap.S antibody

Background:

Synonyms: KIAA0199, SCAP_HUMAN, SREBF chaperone, SREBF chaperone protein, SREBP cleavage activating protein, SREBP cleavage-activating protein, Sterol regulatory element binding protein cleavage-activating protein, Sterol regulatory element-binding protein cleavage-activating protein.

Background: Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.

Gene ID: 22937

UniProt: Q12770

Pathways: SARS-CoV-2 Protein Interactome