HAND2 antibody (AA 51-150) (Biotin)

Catalog No. ABIN7091191

Product Details anti-HAND2 Antibody (Biotin)

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Binding Specificity: AA 51-150

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAND2 antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HAND2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HAND2

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Alternative Name: HAND2 (HAND2 Products)

Background:

Synonyms: DHAND 2, dHAND, DHAND2, Ehand 2, Ehand2, FLJ16260, HAND 2, Hand2, autonomic nervous system and neural crest derivatives-expressed protein 2, heart, Basic helix loop helix transcription factor HAND2, bHLHa26, Class A basic helix-loop-helix protein 26, Deciduum, Deciduum heart autonomic nervous system and neural crest derivatives expressed protein 2 antibody HAND2_HUMAN, Heart and neural crest derivatives expressed 2, Heart and neural crest derivatives expressed protein 2, heart and neural crest derivatives expressed transcript 2, Heart- and neural crest derivatives-expressed protein 2, Hed, Highly similar to dHAND M musculus, MGC125303, MGC125304, Th 2, Th2, Thing 2, Thing2.

Background: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).

Gene ID: 9464

UniProt: P61296

Pathways: Tube Formation, Feeding Behaviour