TXN2 antibody (AA 101-166) (Biotin)

Catalog No. ABIN705973

Product Details anti-TXN2 Antibody (Biotin)

Target: TXN2 (Thioredoxin 2 (TXN2))

Binding Specificity: AA 101-166

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXN2 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Thioredoxin 2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TXN2

Target: TXN2 (Thioredoxin 2 (TXN2))

Alternative Name: Thioredoxin 2 (TXN2 Products)

Synonyms: MT-TRX antibody, MTRX antibody, TRX2 antibody, 31884 antibody, CG31884 antibody, CG3864 antibody, DTrx-2 antibody, DmTrx-2 antibody, DmelTrx-2 antibody, Dmel\\CG31884 antibody, Trx antibody, anon-WO0118547.188 antibody, dmtrx-2 antibody, 2510006J11Rik antibody, AI788873 antibody, Trx2 antibody, zgc:77127 antibody, thioredoxin 2 antibody, thioredoxin-2 antibody, thiol reductase thioredoxin antibody, thioredoxin 2 L homeolog antibody, TXN2 antibody, Trx-2 antibody, LOC409451 antibody, VPA0972 antibody, VS_RS18125 antibody, VCD_000568 antibody, VEA_000083 antibody, trx2 antibody, Txn2 antibody, txn2 antibody, txn2.L antibody

Background:

Synonyms: mitochondrial thioredoxin, MT-TRX, MTRX, thioredoxin 2 precursor, Thioredoxin mitochondrial, Thioredoxin2, TRX 2, TRX2, TXN 2, TXN2.

Background: Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

Gene ID: 25828

Pathways: Cell RedoxHomeostasis