VAPB antibody (AA 51-150)

Catalog No. ABIN705536

Product Details anti-VAPB Antibody

Target: VAPB (VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB))

Binding Specificity: AA 51-150

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VAPB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human VAPB

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for VAPB

Target: VAPB (VAMP (Vesicle-Associated Membrane Protein)-Associated Protein B and C (VAPB))

Alternative Name: VAPB (VAPB Products)

Synonyms: ALS8 antibody, VAMP-B antibody, VAP-B antibody, AI225786 antibody, AI840687 antibody, AI848259 antibody, D2Abb2e antibody, R75548 antibody, VAP33b antibody, Vamp33b antibody, fc05d09 antibody, wu:fa96d05 antibody, wu:fc05d09 antibody, zgc:66045 antibody, vamp-b antibody, vamp-c antibody, vap-b antibody, vap-c antibody, vapb antibody, VAMP associated protein B and C antibody, vesicle-associated membrane protein-associated protein B/C antibody, vesicle-associated membrane protein, associated protein B and C antibody, VAMP (vesicle-associated membrane protein)-associated protein B and C antibody, VAMP (vesicle-associated membrane protein)-associated protein B and C L homeolog antibody, VAPB antibody, Tsp_07972 antibody, Vapb antibody, vapb antibody, vapb.L antibody

Background:

Synonyms: ALS 8, ALS8, D2Abb2e, UNQ484/PRO983, Vamp 33b, VAMP associated 33 kDa protein, VAMP associated protein B and C, VAMP associated protein B, VAMP associated protein B/C, VAMP associated protein C, VAMP B, VAMP B VAMP C, VAMP B/VAMP C, VAMP C, VAMP vesicle associated membrane protein associated protein B and C, Vamp33b, VAMPB, VAMPB/VAMPC, VAMPC, VAP 33b, VAP B, VAP B/VAP C, VAP C, VAP33b, VAPB/VAPC, VAPC antibody Vesicle associated membrane protein associated protein B and C, Vesicle associated membrane protein associated protein B/C, VAPB_HUMAN.

Background: VAPB contains 1 MSP domain and it may play a role in vesicle trafficking. Defects in VAPB are a cause of proximal adult autosomal dominant spinal muscular atrophy [MIM:182980], also called late onset spinal muscular atrophy Finkel type. Spinal muscular atrophies are neurodegenerative disorders characterized by degeneration of lower motor neurons, leading to progressive paralysis muscular atrophy. This form is a late adult onset form of the disease (after age 20 years). The patients show a benign course, most of them remaining ambulatory 10 to 40 years after clinical onset.

Gene ID: 9217

Pathways: ER-Nucleus Signaling