ARHGEF12 antibody (AA 515-615)

Catalog No. ABIN705326

Product Details anti-ARHGEF12 Antibody

Target: ARHGEF12 (rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12))

Binding Specificity: AA 515-615

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF12 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LARG

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ARHGEF12

Target: ARHGEF12 (rho Guanine Nucleotide Exchange Factor (GEF) 12 (ARHGEF12))

Alternative Name: LARG (ARHGEF12 Products)

Synonyms: larg antibody, ARHGEF12 antibody, Larg antibody, pro2792 antibody, LARG antibody, PRO2792 antibody, 2310014B11Rik antibody, AU019857 antibody, mKIAA0382 antibody, Rho guanine nucleotide exchange factor 12 S homeolog antibody, Rho guanine nucleotide exchange factor 12 antibody, Rho guanine nucleotide exchange factor (GEF) 12 antibody, arhgef12.S antibody, ARHGEF12 antibody, arhgef12 antibody, Arhgef12 antibody

Background:

Synonyms: ARHGEF12, KIAA0382, leukemia-associated rho guanine nucleotide exchange factor, Leukemia-associated RhoGEF, PRO2792, Rho guanine exchange factor GEF 12, Rho guanine nucleotide exchange factor GEF 12, Rho guanine nucleotide exchange factor 12, Similar to Mouse Lsc oncogene, ARHGC_HUMAN.

Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia (from EntrezGene). LARG has also been implicated in linking heterotrimeric G proteins to microtubule organisation in regulation of cell polarity.

Gene ID: 23365

Pathways: Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling