Amphiregulin antibody (AA 185-252)

Catalog No. ABIN704996

Product Details anti-Amphiregulin Antibody

Target: Amphiregulin (AREG)

Binding Specificity: AA 185-252

Reactivity: Human, Mouse, Rat, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiregulin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Guinea Pig, Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Amphiregulin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Amphiregulin antibody (ABIN704996)

Jiang, Song, Li, Guo, Wu, Li, Guo, Shi, Bi, Jonas: "Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia." in: EBioMedicine, Vol. 17, pp. 134-144, (2017) (PubMed).

Keiler, Macejova, Dietz, Bolton, Pauli, Chen, van Breemen, Nikolic, Goerl, Muders, Zierau, Vollmer: "Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats." in: The Journal of steroid biochemistry and molecular biology, Vol. 174, pp. 234-241, (2017) (PubMed).

Liu, Fu, Song, Xue, Xia, Liu, Wang, Zhong, Li, Chen, Li, Cai, Li: "Mast Cells Participate in Corneal Development in Mice." in: Scientific reports, Vol. 5, pp. 17569, (2016) (PubMed).

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: Amphiregulin (AREG Products)

Synonyms: AR antibody, CRDGF antibody, SDGF antibody, Sdgf antibody, AREG antibody, AREGB antibody, AREG/SDGF antibody, amphiregulin antibody, AREG antibody, Areg antibody

Background:

Synonyms: AR, SDGF, AREGB, CRDGF, Amphiregulin, Colorectum cell-derived growth factor, AREG

Background: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Gene ID: 374

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway