MHC Class II HLA-DP/DQ/DR antibody (FITC)
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- Target See all MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR) products
- MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This MHC Class II HLA-DP/DQ/DR antibody is conjugated to FITC
- Application
- Please inquire
- Characteristics
- The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.
- Purification
- Purified
- Purity
- >95 %
- Grade
- GMP Grade
- Immunogen
- Priess human B cell line
- Clone
- IVA12
- Isotype
- IgG1 kappa
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
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- Target
- MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
- Alternative Name
- HLA-DR, DP, DQ (HLA-DP/DQ/DR Products)
- Background
- The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.
- Pathways
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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