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ZNF746 antibody

ZNF746 Reactivity: Human, Mouse, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7076272
  • Target See all ZNF746 Antibodies
    ZNF746 (Zinc Finger Protein 746 (ZNF746))
    Reactivity
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 5
    • 1
    Rabbit
    Clonality
    • 5
    • 1
    Polyclonal
    Conjugate
    • 6
    This ZNF746 antibody is un-conjugated
    Application
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human, Rat
    Purification
    Affinity purification
    Immunogen
    Recombinant protein corresponding to Mouse PARIS
  • Application Notes
    WB (H) 1:500-1:1000, IHC/IF (M,R) 1:1500-1:3000/1:1500-1:3000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    ZNF746 (Zinc Finger Protein 746 (ZNF746))
    Alternative Name
    PARIS (ZNF746 Products)
    Synonyms
    PARIS antibody, 2810407L07Rik antibody, AI317225 antibody, Znf746 antibody, RGD1306209 antibody, zinc finger protein 746 antibody, ZNF746 antibody, Zfp746 antibody
    Background
    ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN.
    Molecular Weight
    100 kDa
    Gene ID
    69228
    NCBI Accession
    NP_001156947
    UniProt
    Q3U133
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