WDR81 antibody

Catalog No. ABIN7076221

Product Details anti-WDR81 Antibody

Target: WDR81 (WD Repeat Domain 81 (WDR81))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR81 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse WDR81

Application Details

Application Notes: WB (H,M,R) 1:1000- 1:2000, IHC/IF (M,R) 1:700-1:1400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for WDR81

Target: WDR81 (WD Repeat Domain 81 (WDR81))

Alternative Name: WDR81 (WDR81 Products)

Synonyms: CAMRQ2 antibody, BC054822 antibody, Gm883 antibody, mFLJ00182 antibody, WD repeat domain 81 antibody, WDR81 antibody, Wdr81 antibody

Background: This gene functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization.

Molecular Weight: 65 kDa

Gene ID: 192652

NCBI Accession: NP_620400

UniProt: Q5ND34