UNC13A/Munc13-1 antibody

Catalog No. ABIN7076146

Product Details anti-UNC13A/Munc13-1 Antibody

Target: UNC13A/Munc13-1 (UNC13A) (Unc-13 Homolog A (UNC13A))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC13A/Munc13-1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Munc13-1

Application Details

Application Notes: WB (M,R) 1: 1000-1: 2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for UNC13A/Munc13-1

Target: UNC13A/Munc13-1 (UNC13A) (Unc-13 Homolog A (UNC13A))

Alternative Name: Munc13-1 (UNC13A Products)

Synonyms: Munc13-1 antibody, Unc13h1 antibody, 2410078G03Rik antibody, unc-13 homolog A antibody, unc-13 homolog A (C. elegans) antibody, Unc13a antibody, UNC13A antibody

Background: Unc-13 homolog A (C. elegans) is a protein that in humans is encoded by the UNC13A gene.. This gene encodes a member of the UNC13 family. UNC13A plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool. It is particularly important in most glutamatergic-mediated synapses but not GABA-mediated synapses. It plays a role in dendrite formation by melanocytes and in secretory granule priming in insulin secretion.

Molecular Weight: 194 kDa

Gene ID: 382018

NCBI Accession: NP_001025044

UniProt: Q4KUS2

Pathways: Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis