USP18 antibody

Catalog No. ABIN7076108

Product Details anti-USP18 Antibody

Target: USP18 (Ubiquitin Specific Peptidase 18 (USP18))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP18 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse UBP43

Application Details

Application Notes: WB (H) 1:500-1:1000, IHC/IF (H,M,R) 1:1000-1:2000/1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for USP18

Target: USP18 (Ubiquitin Specific Peptidase 18 (USP18))

Alternative Name: UBP43 (USP18 Products)

Synonyms: ISG43 antibody, UBP43 antibody, bubp43 antibody, 1110058H21Rik antibody, AW047653 antibody, Ubp15 antibody, UBP antibody, USP18 antibody, USP41 antibody, ubiquitin specific peptidase 18 antibody, USP18 antibody, Usp18 antibody

Background: USP18(UBP43) is a 43 kDa protein that is known as an ISG15-deconjugating enzyme and an inhibitor of type I IFN signaling independent of its enzyme activity. USP18 can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. It can be detected two bands(apparent MW of 38 and 35 kDa), the faster migrating one results from proteolytic processing in human primary hepatocytes.

Molecular Weight: 42 kDa

Gene ID: 24110

NCBI Accession: NP_036039

UniProt: Q9WTV6