Trehalase, also known as TREH, TREA or α,α-trehalose glucohydrolase, is a 583 amino acid protein belonging to the glycosyl hydrolase 37 family. Localizing to cell membrane and lipid-anchor, Trehalase is expressed in kidney, liver, and small intestine. Trehalase hydrolyses ingested trehalose, a disaccharide formed by two glucose molecules found mainly in insects, fungi, and plants, into cellular substrate glucose. Isolated trehalose intolerance due to deficiencies of Trehalase can result in gastrointestinal symptoms.