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TCF7 antibody
TCF7
Reactivity: Mouse, Rat
IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TCF7 Antibody
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Target
See all TCF7 Antibodies
TCF7
(Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))
Reactivity
All reactivities for TCF7 antibodies
Mouse, Rat
Host
All hosts for TCF7 antibodies
Rabbit
Clonality
All clonalities for TCF7 antibodies
Polyclonal
Conjugate
All conjugates for TCF7 antibodies
This TCF7 antibody is un-conjugated
Application
All applications for TCF7 antibodies
Immunohistochemistry (IHC), Immunofluorescence (IF)
Cross-Reactivity
Rat
Purification
Affinity purification
Immunogen
Recombinant protein corresponding to Mouse TCF7
Top Product
Discover our top product TCF7 Primary Antibody
Alternatives
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Application Details
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Application Notes
IHC/IF (M,R) 1:600-1:1200/1:600-1:1200
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target Details for TCF7
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Target
TCF7
(Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))
Alternative Name
TCF7 (TCF7 Products )
Synonyms
TCF-1 antibody, AI465550 antibody, Tcf1 antibody, Xtcf-1 antibody, Xtcf1 antibody, tcf-1 antibody, tcf1 antibody, tcf7 antibody, transcription factor 7 antibody, transcription factor 7, T cell specific antibody, transcription factor 7 S homeolog antibody, TCF7 antibody, Tcf7 antibody, tcf7 antibody, tcf7.S antibody
Background
TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Gene ID
21414
NCBI Accession
NP_001300910
UniProt
Q00417
Pathways
WNT Signaling
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