TBC1D7 antibody

Catalog No. ABIN7075849

Product Details anti-TBC1D7 Antibody

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D7 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse TBC1D7

Application Details

Application Notes: WB (H,M,R) 1: 500- 1: 1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TBC1D7

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Alternative Name: TBC1D7 (TBC1D7 Products)

Synonyms: PIG51 antibody, TBC7 antibody, dJ257A7.3 antibody, 2610009C09Rik antibody, TBC1 domain family member 7 antibody, TBC1 domain family, member 7 antibody, TBC1D7 antibody, Tbc1d7 antibody

Background: TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.

Molecular Weight: 36 kDa

Gene ID: 67046

NCBI Accession: NP_001239568

UniProt: Q9D0K0