SUPT3H/SPT3 antibody

Catalog No. ABIN7075767

Product Details anti-SUPT3H/SPT3 Antibody

Target: SUPT3H/SPT3 (SUPT3H) (Suppressor of Ty 3 Homolog (SUPT3H))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUPT3H/SPT3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Mouse, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Human SUPT3H

Application Details

Application Notes: WB (H,M,R) 1:500-1:1000, IHC/IF (M,R) 1:500-1:1500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for SUPT3H/SPT3

Target: SUPT3H/SPT3 (SUPT3H) (Suppressor of Ty 3 Homolog (SUPT3H))

Alternative Name: SUPT3H (SUPT3H Products)

Synonyms: SPT3 antibody, SPT3L antibody, supt3h antibody, MGC75923 antibody, zgc:92246 antibody, SUPT3H antibody, SPT3 homolog, SAGA and STAGA complex component antibody, SPT3 homolog, SAGA and STAGA complex component L homeolog antibody, SUPT3H antibody, supt3h antibody, supt3h.L antibody, Supt3h antibody

Background: The transcription of many RNA polymerase II-dependent genes requires Spt3, a member of the S. cerevisiae SAGA complex. Transcription from delta sequences, the long terminal repeats that flank yeast Ty elements, requires the yeast SPT3 gene. Spt3 and Spt20 work together to recruit TATA-box binding protein (TBP) to the core promoter allowing TBP to bind to SAGA-dependent promoters. Null mutations in the Spt3 gene cause defects in sporulation, diploid filamentous growth, and haploid invasive growth, indicating that Spt3 has an important role in both mating and development pathways in yeast. At the promoters of some genes including yeast HO, HIS3 and TRP3 genes, Spt3 inhibits binding of TBP, resulting in reduced transcription.

Molecular Weight: 36 kDa

Gene ID: 8464

UniProt: O75486