RASGRP3 antibody, zgc:162151 antibody, GRP3 antibody, BC066069 antibody, Gm327 antibody, RAS guanyl releasing protein 3 antibody, RAS guanyl releasing protein 3 (calcium and DAG-regulated) antibody, RAS, guanyl releasing protein 3 antibody, RASGRP3 antibody, rasgrp3 antibody, Rasgrp3 antibody
Background
Members of the RAS (see HRAS, MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.