NOS1AP antibody

Catalog No. ABIN7074844

Product Details anti-NOS1AP Antibody

Target: NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOS1AP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse CAPON/NOS1AP

Application Details

Application Notes: WB (H,M,R) 1:500-1:1000, IHC/IF (M,R) 1:2000-1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for NOS1AP

Target: NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))

Alternative Name: CAPON/NOS1AP (NOS1AP Products)

Synonyms: MGC78853 antibody, Capon antibody, MGC145362 antibody, 6330408P19Rik antibody, CAPON antibody, nitric oxide synthase 1 adaptor protein antibody, nitric oxide synthase 1 adaptor protein L homeolog antibody, nitric oxide synthase 1 (neuronal) adaptor protein a antibody, carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein antibody, chromosome 18 C1orf226 homolog antibody, nitric oxide synthase 1 (neuronal) adaptor protein antibody, NOS1AP antibody, nos1ap.L antibody, nos1apa antibody, LOC609484 antibody, nos1ap antibody, LOC100058633 antibody, C18H1orf226 antibody, Nos1ap antibody

Background: CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels.

Molecular Weight: 56 kDa

Gene ID: 70729

NCBI Accession: NP_001103455

UniProt: Q9D3A8