MED8 antibody

Catalog No. ABIN7074582

Product Details anti-MED8 Antibody

Target: MED8 (Mediator Complex Subunit 8 (MED8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse MED8

Application Details

Application Notes: WB (H,M,R) 1:500-1:1000, IHC/IF (M,R) 1:600-1:1200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for MED8

Target: MED8 (Mediator Complex Subunit 8 (MED8))

Alternative Name: MED8 (MED8 Products)

Synonyms: ARC32 antibody, 2210021A15Rik antibody, AB041805 antibody, MNCb-2386 antibody, zgc:76877 antibody, med8-a antibody, mediator complex subunit 8 antibody, mediator complex subunit 8 L homeolog antibody, component of RNA polymerase II antibody, mediator complex subunit Med8 antibody, MED8 antibody, Med8 antibody, med8 antibody, med8.L antibody

Background: MED8, a component of the Mediator complex, is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. It plays a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins. MED8 has three isoforms with MW 19 kDa, 29 kDa and 33 kDa. And the ubiquitination form will be 38-43 kDa.

Molecular Weight: 29 kDa

Gene ID: 80509

NCBI Accession: NP_001277617

UniProt: Q9D7W5

Pathways: Regulation of Lipid Metabolism by PPARalpha