LAT antibody
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- Target See all LAT Antibodies
- LAT (Linker For Activation of T Cells (LAT))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LAT antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human, Rat
- Purification
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse LAT
- Top Product
- Discover our top product LAT Primary Antibody
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anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibody
LAT Reactivity: Human WB, IP, FACS Host: Mouse Monoclonal LAT-01 unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr191) antibodyLAT Reactivity: Human WB, ELISA, IHC, IP, IF Host: Rabbit Monoclonal 2E4 unconjugated Recombinant Antibody
anti-Linker For Activation of T Cells (LAT) (AA 1-233) antibodyLAT Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 3B11-1D5 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 30-237) antibodyLAT Reactivity: Mouse WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (pTyr161) antibodyLAT Reactivity: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibodyLAT Reactivity: Human WB, IHC, IP, IHC (p) Host: Mouse Monoclonal LAT1111 unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 25-221) antibodyLAT Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (AA 33-227) antibodyLAT Reactivity: Rat WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) antibodyLAT Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Linker For Activation of T Cells (LAT) (Tyr255) antibodyLAT Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB (M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:1000-1:4000/1:500-1:3000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
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- Target
- LAT (Linker For Activation of T Cells (LAT))
- Alternative Name
- LAT (LAT Products)
- Synonyms
- LAT antibody, lat antibody, LAT1 antibody, pp36 antibody, linker for activation of T-cells antibody, linker for activation of T cells antibody, LAT antibody, lat antibody, Lat antibody
- Background
- Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their development This protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads. These direct ligands then mediate the indirect interaction of LAT with proteins such as SLP-76, Vav1 and Itk. PLC-gamma 1, Vav1 and Itk contain pleckstrin homology (PH) domains that interact with the enzymatic product of phosphoinositide-3-kinase (PI3k).
- Molecular Weight
- 38 kDa
- Gene ID
- 16797
- NCBI Accession
- NP_034819
- UniProt
- O54957
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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