ISR-alpha antibody

Catalog No. ABIN7074298

Product Details anti-ISR-alpha Antibody

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ISR-alpha antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Insulin Receptor alpha

Application Details

Application Notes: IHC: 1: 3000-1: 6000
Human, Mouse, Rat: Human, Mouse, Rat
Positive Tissue: endometrial cancer, esophagus cancer, uterus,small intestine

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for ISR-alpha

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Alternative Name: Insulin Receptor alpha (ISR-alpha Products)

Synonyms: CD220 antibody, HHF5 antibody, insulin receptor antibody, INSR antibody

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Gene ID: 16337

UniProt: P15208