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ISR-alpha antibody

ISR-alpha Reactivity: Human, Rat, Mouse IF, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7074298
  • Target See all ISR-alpha Antibodies
    ISR-alpha (Insulin Receptor alpha (ISR-alpha))
    Reactivity
    • 52
    • 41
    • 10
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Rat, Mouse
    Host
    • 45
    • 7
    Rabbit
    Clonality
    • 33
    • 16
    • 3
    Polyclonal
    Conjugate
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ISR-alpha antibody is un-conjugated
    Application
    • 27
    • 26
    • 19
    • 15
    • 12
    • 11
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    Immunofluorescence (IF), Immunohistochemistry (IHC)
    Cross-Reactivity
    Human, Rat
    Purification
    Affinity purification
    Immunogen
    KLH conjugated Synthetic peptide corresponding to Mouse Insulin Receptor alpha
  • Application Notes
    IHC: 1: 3000-1: 6000
    Human, Mouse, Rat: Human, Mouse, Rat
    Positive Tissue: endometrial cancer, esophagus cancer, uterus,small intestine
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    ISR-alpha (Insulin Receptor alpha (ISR-alpha))
    Alternative Name
    Insulin Receptor alpha (ISR-alpha Products)
    Synonyms
    CD220 antibody, HHF5 antibody, insulin receptor antibody, INSR antibody
    Background
    This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
    Gene ID
    16337
    UniProt
    P15208
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