zgc:55557 antibody, HOMER-3 antibody, VESL3 antibody, AW146114 antibody, Vesl-3 antibody, homer scaffolding protein 3b antibody, homer scaffolding protein 3 antibody, homer3b antibody, HOMER3 antibody, Homer3 antibody
Background
HOMER3 is a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides.