H2-AB1 antibody
H2-AB1
Reactivity: Mouse, Rat
IF, IHC
Host: Rabbit
Polyclonal
unconjugated
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- Target See all H2-AB1 products
- H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
- Reactivity
- Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This H2-AB1 antibody is un-conjugated
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Application
- Immunofluorescence (IF), Immunohistochemistry (IHC)
- Cross-Reactivity
- Rat
- Purification
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse H2ab1
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anti-Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1) antibody
H2-AB1 Reactivity: Mouse IF, IHC, WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- IHC/IF (M,R) 1:4000-1:8800
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
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- Target
- H2-AB1 (Histocompatibility 2, Class II Antigen A, beta 1 (H2-AB1))
- Alternative Name
- H2ab1 (H2-AB1 Products)
- Synonyms
- AI845868 antibody, Abeta antibody, H-2Ab antibody, H2-Ab antibody, I-Abeta antibody, IAb antibody, Ia-2 antibody, Ia2 antibody, Rmcs1 antibody, histocompatibility 2, class II antigen A, beta 1 antibody, H2-Ab1 antibody
- Background
- Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells . Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template . Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes . In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes . Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) .
- Gene ID
- 68231
- NCBI Accession
- NP_080903
- UniProt
- Q9CQ70
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