HECTD1 antibody

Catalog No. ABIN7074186

Product Details anti-HECTD1 Antibody

Target: HECTD1 (HECT Domain Containing 1 (HECTD1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HECTD1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse HECTD1

Application Details

Application Notes: IHC/IF (R) 1:1000-1:2000/1:1000-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for HECTD1

Target: HECTD1 (HECT Domain Containing 1 (HECTD1))

Alternative Name: HECTD1 (HECTD1 Products)

Background: HECTD1 (E3 ubiquitin-protein ligase, which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion . Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells impairs their emigration and is consequently essential for the correct development of the cranial neural folds and neural tube closure.It is also involved in sporadic Parkinson's disease.

UniProt: Q69ZR2

Pathways: Tube Formation, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection