GTF2B antibody

Catalog No. ABIN7074034

Product Details anti-GTF2B Antibody

Target: GTF2B (General Transcription Factor IIB (GTF2B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTF2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse TFIIB

Application Details

Application Notes: WB (H,M,R) 1: 500-1: 1000, IHC/IF (H,M,R) 1:500-1:1500/1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for GTF2B

Target: GTF2B (General Transcription Factor IIB (GTF2B))

Alternative Name: TFIIB (GTF2B Products)

Synonyms: CG5193 antibody, Dmel\\CG5193 antibody, TFIIB antibody, Tfiib antibody, TfllB antibody, dTFIIB antibody, dTfIIB antibody, dmTFIIB antibody, gtf2b antibody, tf2b antibody, tfiib antibody, XLTFIIB antibody, TF2B antibody, wu:fc44c11 antibody, zgc:66258 antibody, Transcription factor IIB antibody, transcription initiation factor iib antibody, transcription initiation factor IIB antibody, transcription initiation factor IIB 2 antibody, Transcription initiation factor IIB antibody, general transcription factor 2B S homeolog antibody, general transcription factor 2B L homeolog antibody, general transcription factor IIB antibody, TfIIB antibody, CNF01950 antibody, tfb antibody, CC1G_14689 antibody, HacjB3_18813 antibody, HALXA_RS07110 antibody, HALXA_RS16310 antibody, tf2b antibody, LOC100283348 antibody, gtf2b.S antibody, gtf2b.L antibody, GTF2B antibody, gtf2b antibody, Gtf2b antibody

Background: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA .Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex .Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle . Associates with chromatin to core promoter- specific regions .Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner,Modulates transcription start site selection . Exhibits also autoacetyltransferase activity that contributes to the activated transcription .

Molecular Weight: 35 kDa

Gene ID: 229906

NCBI Accession: NP_663521

UniProt: P62915