DOCK2 antibody

Catalog No. ABIN7073706

Product Details anti-DOCK2 Antibody

Target: DOCK2 (Dedicator of Cytokinesis 2 (DOCK2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK2 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse DOCK2

Application Details

Application Notes: WB (H,M,R) 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for DOCK2

Target: DOCK2 (Dedicator of Cytokinesis 2 (DOCK2))

Alternative Name: DOCK2 (DOCK2 Products)

Synonyms: AI662014 antibody, AW122239 antibody, CED-5 antibody, Hch antibody, MBC antibody, dedicator of cytokinesis 2 antibody, dedicator of cyto-kinesis 2 antibody, DOCK2 antibody, dock2 antibody, Dock2 antibody

Background: The DOCK2 gene encodes dedicator of cytokinesis 2 (DOCK 2), a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. DOCK 2 participates in the cytoskeletal rearrangements that are required for lymphocyte migration in response of chemokines. DOCK 2 may also participate in IL-2 transcriptional activation through the activation of Rac 2. DOCK 2 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. The DOCK 2 protein also co-localizes with F-Actin, and demonstrates expression in several human tissues, with the highest levels observed in peripheral blood leukocytes, thymus, spleen and liver.

Molecular Weight: 220 kDa

Gene ID: 94176

NCBI Accession: NP_203538

UniProt: Q8C3J5