CYB561 antibody

Catalog No. ABIN7073661

Product Details anti-CYB561 Antibody

Target: CYB561 (Cytochrome B-561 (CYB561))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYB561 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse Pyruvate Dehydrogenase E2

Application Details

Application Notes: IHC/IF (R) 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for CYB561

Target: CYB561 (Cytochrome B-561 (CYB561))

Alternative Name: Pyruvate Dehydrogenase E2 (CYB561 Products)

Synonyms: CYB561A1 antibody, FRRS2 antibody, ECK1410 antibody, JW5224 antibody, MGC69260 antibody, zgc:193680 antibody, zgc:193701 antibody, ACYB-1 antibody, MBB18.18 antibody, MBB18_18 antibody, cytochrome B561-1 antibody, xcyt antibody, cytochrome b561 antibody, cytochrome b-561 antibody, cytochrome B561-1 antibody, cytochrome b561 L homeolog antibody, CYB561 antibody, cytb561 antibody, cybB antibody, LOC5576849 antibody, LOC5576850 antibody, Cyb561 antibody, cyb561 antibody, CYB-1 antibody, cyb561.L antibody, LOC100347599 antibody

Background: This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95 % of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.

Gene ID: 235339

UniProt: Q8BMF4