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CRTC1 antibody
CRTC1
Reactivity: Mouse, Rat
IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CRTC1 Antibody
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Target
See all CRTC1 Antibodies
CRTC1
(CREB Regulated Transcription Coactivator 1 (CRTC1))
Reactivity
All reactivities for CRTC1 antibodies
Mouse, Rat
Host
All hosts for CRTC1 antibodies
Rabbit
Clonality
All clonalities for CRTC1 antibodies
Polyclonal
Conjugate
All conjugates for CRTC1 antibodies
This CRTC1 antibody is un-conjugated
Application
All applications for CRTC1 antibodies
Immunohistochemistry (IHC), Immunofluorescence (IF)
Cross-Reactivity
Rat
Purification
Affinity purification
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse TORC1
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Alternatives
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Application Details
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Application Notes
IHC/IF (M,R) 1:400-1:800
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target Details for CRTC1
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Target
CRTC1
(CREB Regulated Transcription Coactivator 1 (CRTC1))
Alternative Name
TORC1 (CRTC1 Products )
Synonyms
MECT1 antibody, TORC-1 antibody, TORC1 antibody, WAMTP1 antibody, AI413414 antibody, Mect1 antibody, R74955 antibody, mKIAA0616 antibody, CRTC1 antibody, crtc1 antibody, fc68c05 antibody, pde4cb antibody, si:ch211-255d18.1 antibody, si:ch211-255d18.8 antibody, wu:fc68c05 antibody, CREB regulated transcription coactivator 1 antibody, CREB regulated transcription coactivator 1b antibody, CRTC1 antibody, Crtc1 antibody, crtc1 antibody, crtc1b antibody
Background
CRTC1, also named as MECT1, TORC1, and WAMTP1, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. CRTC1 acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. It enhances the interaction of CREB1 with TAF4. CRTC1 regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. It is a potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.
Gene ID
382056
NCBI Accession
NP_001004062
UniProt
Q68ED7
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