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CD35 antibody
CR1
Reactivity: Human, Mouse, Rat
WB, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CD35 Antibody
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Target
See all CD35 (CR1) Antibodies
CD35 (CR1)
(Complement Component Receptor 1 (CD35) (CR1))
Reactivity
All reactivities for CD35 antibodies
Human, Mouse, Rat
Host
All hosts for CD35 antibodies
Rabbit
Clonality
All clonalities for CD35 antibodies
Polyclonal
Conjugate
All conjugates for CD35 antibodies
This CD35 antibody is un-conjugated
Application
All applications for CD35 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Cross-Reactivity
Mouse, Rat
Purification
Affinity purification
Immunogen
KLH conjugated Synthetic peptide corresponding to Human CD35
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Alternatives
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Application Details
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Application Notes
WB (M,R) 1:500-1:1000, IHC/IF (H,R) 1:650-1:1300
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Target Details for CD35
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Target
CD35 (CR1)
(Complement Component Receptor 1 (CD35) (CR1))
Alternative Name
CD35 (CR1 Products )
Synonyms
C3BR antibody, C4BR antibody, CD35 antibody, KN antibody, C3DR antibody, CD21 antibody, Cr-1 antibody, Cr-2 antibody, Cr1 antibody, CR1-L antibody, CR2 antibody, CR1 antibody, complement C3b/C4b receptor 1 (Knops blood group) antibody, complement receptor 2 antibody, complement component (3d/Epstein Barr virus) receptor 2 antibody, complement receptor type 1 antibody, CR1 antibody, Cr2 antibody, CR2 antibody, LOC718120 antibody
Background
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.
Molecular Weight
224 kDa
Gene ID
1378
NCBI Accession
NP_000564
UniProt
P17927
Pathways
Complement System , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Endopeptidase Activity
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