CD3 antibody

Catalog No. ABIN7073386

Product Details anti-CD3 Antibody

Target: CD3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting (WB)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse CD3

Application Details

Application Notes: WB (H,M,R) 1:500-1:1000, IHC/IF (H,M,R) 1:250-1:1000/1:250-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-CD3 antibody (ABIN7073386)

Feng, Yang, Luo, Sun, Lv, Wan, Guan, Xiao, Liu, Li, Dong, Yang: "The kinase PDK1 regulates regulatory T cell survival via controlling redox homeostasis." in: Theranostics, Vol. 11, Issue 19, pp. 9503-9518, (2022) (PubMed).

He, Wang, Lu, Yang, Xue, Zhu, Zhang, Fan: "Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations." in: Oncogene, Vol. 40, Issue 2, pp. 355-368, (2021) (PubMed).

Chen, Gu, Jia, Liu, Liu, Liu, Xu, Lin, Lin, Liu, Chen, Xu, Yuan, Zhang, Zhang, Xiao, Gu: "Optimization Strategy for Generating Gene-edited Tibet Minipigs by Synchronized Oestrus and Cytoplasmic Microinjection." in: International journal of biological sciences, Vol. 15, Issue 12, pp. 2719-2732, (2020) (PubMed).

Target Details for CD3

Target: CD3

Alternative Name: CD3 (CD3 Products)

Synonyms: CD3 antibody, AI504783 antibody, CD3epsilon antibody, T3e antibody, cd3-gamma antibody, cd3g antibody, cd3g-a antibody, cd3g/d antibody, cd3gd antibody, t3g antibody, CD3e molecule antibody, CD3d molecule antibody, CD3 antigen, epsilon polypeptide antibody, CD3g molecule S homeolog antibody, CD3E antibody, CD3D antibody, Cd3e antibody, cd3g.S antibody

Background: The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.

Molecular Weight: 21 kDa

Gene ID: 12501

NCBI Accession: NP_031674

UniProt: P22646

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway